OXIS INTERNATIONAL

OXIS INTERNATIONAL, INC. is completing a strategic and timely transformation towards its goal of becoming a leading nutraceutiecal, cosmecuetical and therapeutics company. OXIS was founded in 1966 and for many years focused on diagnostics while developing some of its unique patented compounds and acquiring significant expertise in the field of oxidative stress including ERGO. OXIS is now focusing its business on its rich science background and its related 12 key patents and 7 patent pending applications and other new research.
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During the past twelve months, OXIS has made significant strides towards its new objectives including:
    * Divesting all of it diagnostics businesses to strategically focus the business on neutraceuticals, cosmeceuticals and therapeutic compounds,
    * Building a new strong team of Executive Management, Board of Directors, and Scientific Advisory Board,
    * Raising new capital to fund its new strategy, and
    * Increasing the equity value and liquidity of its common stock and regaining Bulletin Board trading status.
Investors and others interested in learning more about OXIS are invited to review the following additional information.

Product Focus
Our products include therapeutic nutraceutical products, cosmeceutical products and proprietary formulations and clinical products that are developed internally and/or out-licensed to biotech and pharmaceutical companies as drug candidates. We focus on naturally occurring protective substances since they are more likely to be both safe and efficacious. Our primary products incorporate and emphasize the multifaceted “super antioxidant” compound, L-­Ergothioneine (“ERGO”), as a key component. We own several patents and pending applications related to ERGO that cover current and planned products relevant to our nutraceutical and cosmecuetical businesses. Our patents and patent applications address ERGO’s protective effects and activities and the ERGO manufacturing process.




About Ergothioneine
ERGOTHIONEINE…THE SUPER ANTIOXIDANT FOR NUTRACEUTICAL, COSMECEUTICAL AND THERAPEUTICS
ERGO is naturally occurring, water soluble, amino acid multifaceted antioxidant produced by microbes in the soil and most commonly found in (but not produced by) various species of mushrooms and grapes, meats and dairy products. However, it is not commercially practical to extract ERGO from these natural sources and it essentially impossible to ingest a diet that provides enough ERGO to take full advantage of its potential health benefits. Humans and most animals typically have low levels of ERGO since the amount of ERGO in the diet is relatively small.  

INTELLECTUAL PROPERTY AND SCIENCE BACKGROUND
Our intellectual property for ERGO includes three patents and two patent pending applications that cover the synthesis of highly-purified ERGO and the protective effect of ERGO on mitochondria and other pivotal body structures and functions. A number of peer reviewed scientific papers referenced in the Monograph  [create link] on this website indicate that ERGO is one of the most potent, multifaceted biological compounds with both appreciable antioxidant, anti-inflammatory, neuroprotective and other protective properties. ERGO acts by itself, or in combination with other natural compounds to improve the body’s own intrinsic defenses against oxidative stress. Accordingly, Oxis is focusing its efforts on developing products that deliver the benefits of ERGO taken by itself and in combination with other elements that enhance various health protective systems.

BENEFITS OF ERGO
Some of the potential benefits of ERGO include its ability to:
    * Conserve and maintain the levels of other antioxidants such as Vitamin E, Vitamin C and glutathione;
    * Increase respiration and the oxidation of fat (possibly contributing to increased energy and exercise capacity);
    * Protect mitochondria from damage (this is important because potentially damaging reactive oxygen species are generated when oxygen is normally metabolized in mitochondria,
    * Reduce the damaging effects of environmental ultraviolet radiation (likely to be important in protecting the eyes against cataract producing oxidative injury);
    * Neutralize increased oxidative stress by providing an ROS (reactive oxygen species) and RNS (reactive nitrogen species) scavenging capacity, a property that protects key molecules in the body; and,

Protect against the effects of neurotoxins that are believed to have a casual role in the development and progression of cognitive decline.