OXIS INTERNATIONAL

OXIS INTERNATIONAL, INC. is completing a strategic and timely transformation towards its goal of becoming a leading nutraceutiecal, cosmecuetical and therapeutics company.

OXIS was founded in 1966 and for many years focused on diagnostics while developing some of its unique patented compounds and acquiring significant expertise in the field of oxidative stress including ERGO. OXIS is now focusing its business on its rich science background and its related 12 key patents and 7 patent pending applications and other new research.

During the past twelve months, OXIS has made significant strides towards its new objectives including:
    * Divesting all of it diagnostics businesses to strategically focus the business on neutraceuticals, cosmeceuticals and therapeutic compounds,
    * Building a new strong team of Executive Management, Board of Directors, and Scientific Advisory Board,
    * Raising new capital to fund its new strategy, and
    * Increasing the equity value and liquidity of its common stock and regaining Bulletin Board trading status.

Investors and others interested in learning more about OXIS are invited to review the following additional information.

http://www.oxis.com
Oxis on Twitter
Oxis on facebook

OXIS’ consumer products strategy addresses very important health concerns including aging and age-related disorders that are increasing with trends in US demographics.  These concerns include:
    * Brain health
    * Immunity against diseases
    * Anti-aging/skin health
    * Inflammation
    * Detoxification
    * Blood sugar regulation


BXT 51072 (OUR LEAD COMPOUND) AND GLUTATHIONE PEROXIDASE (GPX) MIMICKING COMPOUNDS: BXT-51072 is a low molecular weight, orally active, organoselenium catalytic mimic of one of the major cellular protective antioxidant enzyme, glutathione peroxidase (GPx) which uses glutathione as substrate.  BXT-51072 can be taken orally or administered intravenously. In addition to its direct hydrogen peroxide (a central reactive oxygen species) neutralizing capabilities, BXT-51072 regulates secondary inflammatory processes by preventing the activation and release of inflammatory mediators such as cytokines, adhesion molecules and inflammatory enzymes.

OXIS planning two product launches for summer 2010
    * “Ergo-Pur™”  - ERGO-Pur is a pure form of our highly potent multifaceted antioxidant which we anticipate will be used in some cases in concert with:
    * “Ergo-Plex™” – ERGO-Plex is a combination of ERGO plus other functional nutraceutical ingredients directed at Joint Health.

TREATING OXIDATIVE STRESS
Oxidative stress is caused by the unchecked activities of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Both ROS and RNS are highly reactive, unstable molecules that, in healthy cells, are created and neutralized as part of normal cell life. However, if the production of penny stocks & free radicals and ROS/RNS exceeds the body's natural defense mechanisms, oxidative damage to vital molecules in the body can occur and may lead to cell dysfunction and cell death.  Oxidative stress is also caused by inflammation, exposure to cigarette smoke, pollution, UV light, radiation, certain drugs and other conditions.  Oxidative stress also increases as we age.

Therapeutic Compounds - Antioxidant

Therapeutic compounds and clinical products are actual remedies that can be used to treat diseases. Oxis has several therapeutic compounds that are available to be licensed including anti-inflammatory and several therapeutic antioxidant mimics with potential applications in the treatment of neurodegenerative (Alzheimer’s and Parkinson’s), cardiovascular diseases, diabetes and other conditions.

TREATING OXIDATIVE STRESS
Oxidative stress is caused by the unchecked activities of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Both ROS and RNS are highly reactive, unstable molecules that, in healthy cells, are created and neutralized as part of normal cell life. However, if the production of free radicals and ROS/RNS exceeds the body's natural defense mechanisms, oxidative damage to vital molecules in the body can occur and may lead to cell dysfunction and cell death.  Oxidative stress is also caused by inflammation, exposure to cigarette smoke, pollution, UV light, radiation, certain drugs and other conditions.  Oxidative stress also increases as we age.
OXIS' goal is to control both direct cellular abnormalities and damage from ROS and RNS.  One of ways that this can be accomplished is by using OXIS’s compounds to modulate the activation of certain molecules called transcription factors. Transcription factors are the central control switches in the body that can trigger and modulate a cascade of interrelated events.   Activation of transcription factors by ROS/RNS can accelerate inflammatory responses that can cause and contribute to cell death in degenerative and other diseases.  OXIS is in the process of early stage development of therapeutic molecules that have the ability to counteract some of these unwanted responses and perhaps be able to counteract different health abnormalities. penny stocks & free radical are prominent.
http://www.oxis.com
Oxis on Twitter
Oxis on facebook



BXT 51072 (OUR LEAD COMPOUND) AND GLUTATHIONE PEROXIDASE (GPX) MIMICKING COMPOUNDS
BXT-51072 is a low molecular weight, orally active, organoselenium catalytic mimic of one of the major cellular protective antioxidant enzyme, glutathione peroxidase (GPx) which uses glutathione as substrate.  BXT-51072 can be taken orally or administered intravenously. In addition to its direct hydrogen peroxide (a central reactive oxygen species) neutralizing capabilities, BXT-51072 regulates secondary inflammatory processes by preventing the activation and release of inflammatory mediators such as cytokines, adhesion molecules and inflammatory enzymes. The exact mechanism is unclear but there is evidence that BXT-51072 may function by inhibiting fundamental nuclear transcription mechanisms that govern and regulate inflammation and other significant processes.   BXT-51072 was initially developed for use in the treatment of inflammatory bowel diseases, and has demonstrated efficacy and safety in a preliminary Phase 2 study for ulcerative colitis.

LIPID SOLUBLE ANTIOXIDANT (LSA) COMPOUNDS
OXIS' LSA Molecules are designed to mimic the activity of the body's natural cell membrane-protecting antioxidant, Vitamin E.  LSA molecules are 20 to 40 times more potent than Vitamin E and move into cell membranes much more quickly, giving them the opportunity to be effective in areas not necessarily penetrated by the natural Vitamin E. The primary disease targets for this series of molecules will include neurodegenerative diseases such as Alzheimer and Parkinson disease and cardiovascular diseases in additional to other possibilities.

Superoxide Dismutase (SOD) is a naturally occurring enzyme found in essentially all living organisms. SOD catalyzes the destruction of the “Superoxide” molecule. This enzyme has been used in Spain for many years in the treatment of Chronic Inflammatory Joint Diseases and in the prevention of Radiation Fibrosis and scarring in patients with Colorectal Carcinoma undergoing radiation treatment. Oxis has several patents related to SOD uses and continues to enhance its IP portfolio with additional SOD related technologies.

FDA APPROVED CLINICAL PRODUCT
Palosein (Orgotein) is an OXIS FDA approved drug for the treatment of arthritic inflammation in veterinary use called Palosein (NAD/NADA # 045-863).  Palosein is a form of Superoxide Dismutase (SOD) that is derived from bovine liver. Oxis is currently in the process of re-certifying its manufacturing process and is actively seeking partnerships with distributors to sell Palosein into the veterinary channel. Oxis will provide additional information on Palosein as further progress is achieved

FURTHER INFORMATION
Please contact us for additional technical information on our therapeutic compounds and/or to discuss licensing opportunities.

OXIS Cares for Anti aging

OXIS’ CONSUMER PRODUCTS…BASED ON POWERFUL NATURAL SUBSTANCES
OXIS is developing and plans to sell Nutraceutical and Cosmecuetical products featuring natural ingredients believed to have beneficial effects on human health. OXIS’ first products will include L-Ergothioneine (ERGO) as a key component. ERGO is a very powerful, multifaceted antioxidant. The remarkable properties of ERGO are described in detail in the Ergothioneine section of this website. OXIS has patented the synthesis process for L-Ergothioneine and has outsourced product manufacturing to a company that can provide ERGO in commercial and GMP produced quantities to meet our product needs. OXIS’ consumer products strategy addresses very important health concerns including aging and age-related disorders that are increasing with trends in US demographics.

These concerns include:
    * Brain health
    * Immunity against diseases
    * Anti-aging/skin health
    * Inflammation
    * Detoxification
    * Blood sugar regulation
http://www.oxis.com
Oxis on Twitter
Oxis on facebook

Our market entry and expansion strategy includes potential alliances with highly respected, credible and iconic thought leaders in each product category. Typically, these individuals or companies have established consumer followings or the ability to build meaningful and loyal customer bases. Our plan is to develop on-going relationships with our customers and to be regarded as a health partner to individuals of all ages based on the products and educational content that we provide to them.

Channels for communicating our message and building sales being established include:
    * Multi-level marketing
    * Internet sales
    * TV Infomercials
    * Long and short form radio infomercials
    * Direct mail
    * Traditional retail approaches

We are planning two product launches for summer 2010
    * “Ergo-Pur™”  - ERGO-Pur is a pure form of our highly potent multifaceted antioxidant which we anticipate will be used in some cases in concert with:
    * “Ergo-Plex™” – ERGO-Plex is a combination of ERGO plus other functional nutraceutical ingredients directed at Joint Health.

Other products are being evaluated and include a line of skin care products. In addition we will develop other nutraceuticals and functional foods such as nutrition bars, energy beverages and single serve shots that lend themselves to traditional retail distribution

OXIS INTERNATIONAL

OXIS INTERNATIONAL, INC. is completing a strategic and timely transformation towards its goal of becoming a leading nutraceutiecal, cosmecuetical and therapeutics company. OXIS was founded in 1966 and for many years focused on diagnostics while developing some of its unique patented compounds and acquiring significant expertise in the field of oxidative stress including ERGO. OXIS is now focusing its business on its rich science background and its related 12 key patents and 7 patent pending applications and other new research.
http://www.oxis.com
Oxis on Twitter
Oxis on facebook
During the past twelve months, OXIS has made significant strides towards its new objectives including:
    * Divesting all of it diagnostics businesses to strategically focus the business on neutraceuticals, cosmeceuticals and therapeutic compounds,
    * Building a new strong team of Executive Management, Board of Directors, and Scientific Advisory Board,
    * Raising new capital to fund its new strategy, and
    * Increasing the equity value and liquidity of its common stock and regaining Bulletin Board trading status.
Investors and others interested in learning more about OXIS are invited to review the following additional information.

Product Focus
Our products include therapeutic nutraceutical products, cosmeceutical products and proprietary formulations and clinical products that are developed internally and/or out-licensed to biotech and pharmaceutical companies as drug candidates. We focus on naturally occurring protective substances since they are more likely to be both safe and efficacious. Our primary products incorporate and emphasize the multifaceted “super antioxidant” compound, L-­Ergothioneine (“ERGO”), as a key component. We own several patents and pending applications related to ERGO that cover current and planned products relevant to our nutraceutical and cosmecuetical businesses. Our patents and patent applications address ERGO’s protective effects and activities and the ERGO manufacturing process.




About Ergothioneine
ERGOTHIONEINE…THE SUPER ANTIOXIDANT FOR NUTRACEUTICAL, COSMECEUTICAL AND THERAPEUTICS
ERGO is naturally occurring, water soluble, amino acid multifaceted antioxidant produced by microbes in the soil and most commonly found in (but not produced by) various species of mushrooms and grapes, meats and dairy products. However, it is not commercially practical to extract ERGO from these natural sources and it essentially impossible to ingest a diet that provides enough ERGO to take full advantage of its potential health benefits. Humans and most animals typically have low levels of ERGO since the amount of ERGO in the diet is relatively small.  

INTELLECTUAL PROPERTY AND SCIENCE BACKGROUND
Our intellectual property for ERGO includes three patents and two patent pending applications that cover the synthesis of highly-purified ERGO and the protective effect of ERGO on mitochondria and other pivotal body structures and functions. A number of peer reviewed scientific papers referenced in the Monograph  [create link] on this website indicate that ERGO is one of the most potent, multifaceted biological compounds with both appreciable antioxidant, anti-inflammatory, neuroprotective and other protective properties. ERGO acts by itself, or in combination with other natural compounds to improve the body’s own intrinsic defenses against oxidative stress. Accordingly, Oxis is focusing its efforts on developing products that deliver the benefits of ERGO taken by itself and in combination with other elements that enhance various health protective systems.

BENEFITS OF ERGO
Some of the potential benefits of ERGO include its ability to:
    * Conserve and maintain the levels of other antioxidants such as Vitamin E, Vitamin C and glutathione;
    * Increase respiration and the oxidation of fat (possibly contributing to increased energy and exercise capacity);
    * Protect mitochondria from damage (this is important because potentially damaging reactive oxygen species are generated when oxygen is normally metabolized in mitochondria,
    * Reduce the damaging effects of environmental ultraviolet radiation (likely to be important in protecting the eyes against cataract producing oxidative injury);
    * Neutralize increased oxidative stress by providing an ROS (reactive oxygen species) and RNS (reactive nitrogen species) scavenging capacity, a property that protects key molecules in the body; and,

Protect against the effects of neurotoxins that are believed to have a casual role in the development and progression of cognitive decline.

Portable AppRemover 2.2.2.1

AppRemover is a free of charge software that can help you to completely remove antivirus and antispyware products from your computer. As you may know already not all the files are removed when uninstalling an antivirus or antispyware but this is the perfect tool to do it.

Use App Remover:
+ When replacing one security application with another
+ When competing security applications tie up your computer
+ When the applications built-in uninstall process fails
+ When you have forgotten the application password

Whats New in AppRemover 2 :
+ General enhancement of product automatic uninstallation on 64bit operating systems.
+ Improved heuristic detection of products.
+ Fix the issue of API/CLI not returning correct supported level of products.
+ Added new command line switch for displaying all automatic removal supported products in CLI.
+ Improved display of proper product marketing names on AppRemover GUI.
+ Main GUI change for isolating automatic removal supported products and heuristically detected products.
+ GUI enhancement of adding QA tested results and community feedback information to detected product entries.
+ GUI enhancement for displaying in-process FAQ page for special handling of several exceptional products.
Download  AppRemover

USB Lock 2.5

'USB Lock 2.5' is one of the Best application that i found upto now, because its an all in one locker. Normally if one doesn't have an internet connection / In Network, the intruder obviously enters through USB / DVD Drive-Floppy / Direct interaction to system attack. The software which i am talking about takes care of all the things that i am talking, it also got an additional function which last but not the least 'Folder Protection'.

What else do you need ?
1. USB Protection
2. DVD / Floppy drive Protection
3. System Lock
4. Folder Lock with a visible mode locker.

Ok lets see how the interfaces & things are working out on all different protection modes.

1. 'USB drive locker'
a. Press the button 'Protect' under the 'USB Storage Drives' and close the application.
b. From the very next moment soon it doesn't allow any usb connections to the system. Any USB device connected to the system is warned with a blank screen message to remove the usb device, else the system is going to be shutdown in another 15 seconds.

c. If the user wants to connect any usb devices to the system he need to open enter the USB lock software and click on unprotect button under 'USB Storage Drives' section.

2. Folder Protection:
a. Another excellent feature is the folder lock protection, its too simply to lock a folder JDD(Just drag and drop) into folder protection section.
b. Any folder that you want to lock it, just drag and drop the folder into the area mentioned below in red.

c. Your folder will be visible to every one and the folder size remains the same too, But "FOLDER CANNOT BE OPENED". If any one tries to open a locked folder it just opens an internet browser and shows a blank loading page. Below is an example of a locked folder.

d. To unlock the protected folder, once again drag and drop the protected folder into the same area mentioned previously. Unless u perform this action you can never get back your files back.
e. Without a drawback there's never a complete tool in this world, like the same - The protected folder can be deleted with even unlocking it.

3. CD-DVD / Floppy drive protection:
a. The protection with the DVD/Floppy drives is not just like USB protection, its entirely different but one thing is common i.e. to click on protect button to lock the drive.
b. After clicking on protect button, simply you wont see your DVD/Floppy drive icons in 'My Computer'. It means they get disappeared, unless you again unlock them using 'Unprotect' button you will not be able to see your tray drives appeared back.

4. PC Lock / PC Lock Transparent:
a. PC Lock generally gives you a blank screen where you will be asked a password to unlock the system.
b. PC Lock Transparent doesn't show you the black screen and ask to enter the password, unless you perform any mouse/keyboard action till then you will be show your normal desktop.
Download USB Lock 2.5

Face Off Max 3.1.2.8

Face Off Max allows you to create a fun image by pasting your face on any other body using any photo or template.Haven't you ever wondered how you would look if you had another body? Wouldn't it be great to see your face in a celebrity group or on a magazine cover? Now Face Off Max enables you to embarrass your coworkers, make yourself look cool and make your friends look like dweebs all with a few clicks of the mouse.

Our amazingly simple and easy interface, step-by-step instruction and hundreds of
fantastic templates allow anyone to be a professional artist. Share your creations with your friends. It's perfect with facebook, MySpace, email, blogs, spaces, ecards, fakes, jokes and many more!

Key Features:--
--------------------
- Easy to Use
- Amazingly simple and easy interface allows anyone to be an artist.
- Real Skin Blending
- Make headswaps look better than other photo editors.
- Fantastic Template
- Hundreds of cool templates designed by professional artists.
- Easy to Share
- Perfect for Email, myspace, facebook, ecards, fakes, jokes and many more!
Download  Face Off Max 3.1.2.8

PowerISO 4.7

PowerISO is one of the top virtual drivers available now presently, the new version 4.7 included many imaging formats.
DAA (PowerISO: which is already included from the previous versions of PowerISO.
- What is the advantage to use DAA instead of ISO Image and other CD/DVD image to backup CD/DVD? The first and important advantage of using DAA is that can reduce the size of image file, it saves both in the compression and in the saving of disk sector cluster, DAA is a compressed format, It compresses raw CD/DVD data with high quality compression-method. Second, You can backup secret and private CD/DVD using DAA. Especially, It has the advantage to transfer CD/DVD through the Internet. DAA provides both the feature of password-protected for denying the access from any unauthorized user and other feature of data encryption for defeating any sniffer and hacker.

.ashdisc is one of the new virtual image that was included on this 4.7 version, its origin is from ashampoo studio. Ashampoo is also one of the good software that had good talk in market.

PowerISO is a powerful CD/DVD image file processing tool, which allows you to open, extract, create, edit, compress, encrypt, split and convert ISO files, and mount these files with internal virtual drive. It can process almost all CD-ROM image files including ISO and BIN.

Download PowerISO 4.7

Easy Net Switch v6.6

Do you use your computer in different locations or networks?
Easy Net Switch enables you to automatically select correct IP addresses, proxys, drive mappings, default printers and much more with a single click.
It's not only an IP or Network profiles switcher, but also a handy tool that helps you to use your computer in multiple networks easily!

Advantages of Easy Net Switch:-
-----------------------------------
- Lightweight, efficiency and stable
Small file size and memory usage, never slow down your computer. Activate profiles "on the fly", and no reboot required!
- Flexible and easy to use
Change proxy frequently? Or only want to map the network drivers automatically? With Easy Net Switch, you can create the most flexible net profiles for different purpose.
- Show IP address on the desktop wallpaper !
With it's building DKInfo™ engine, Easy Net Switch can display current IP addresses info on the desktop wallpaper. It's the easiest way to monitor your computer's IP addresses info.
- Useful building network tools
Tools with easy to use GUI can help you to diagnose your possible network problems. Including Ping, Trace route (Tracert), IPConfig and much more.
- Auto-capture current network settings
By clicking a button, your current computer's configuration will be imported into a profile automatically. Your can share or apply it again at anytime.
- Intelligent profile export and import wizard
Using the "best match" approach, one can easily backup, restore or share their network profiles with others including the WiFi settings.
Download Easy Net Switch v6.6